Microwave-Assisted Regioselective Suzuki Coupling of 2,4-Dichloropyrimidines with Aryl and Heteroaryl Boronic Acids

Suzuki coupling reaction has been often used for the preparation of a diverse set substituted pyrimidines. In this study, 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids was investigated. A thorough screening conditions use microwave irradiation led to very efficient straightforward synthetic procedure providing C4-substituted pyrimidines in good excellent yields. Short time (15 min) extremely low catalyst loading (0.5 mol%) are main advantages our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be quick low-cost regioselective pyrimidine rings.